Triméthoprime

Trimethoprim appears as a white crystalline, odorless powder that is sparingly soluble in water. It is stable at room temperature but sensitive to light. This compound acts as a selective inhibitor of bacterial dihydrofolate reductase, blocking the synthesis of folic acid, which is essential for bacterial growth. Due to its specific chemical structure, it is often combined with sulfonamides to enhance its antibacterial efficacy.

Applications:

• Pharmaceutical Industry:
  Widely used in the formulation of antibacterial drugs, particularly for the treatment of urinary tract infections, respiratory infections, and gastrointestinal infections. It is commonly combined with sulfamethoxazole in formulations such as cotrimoxazole.

• Scientific Research:
  Utilized in bacterial resistance studies, molecular biology assays, and research on bacterial DNA synthesis mechanisms.

• Veterinary Industry:
  Used to treat bacterial infections in animals, especially in poultry and livestock farming.

• Cosmetic Products:
  While its use is limited, trimethoprim can be incorporated into certain dermatological formulations to treat bacterial skin conditions, such as acne and skin infections.